Alabama-Charleston Southern will kick off at 4 p.m. ET (SEC Network) on Nov. 21.
Charleston Southern is ranked No. 11 in the FCS with an 8-1 record. The Buccaneers have not lost since Sept. 12, when they fell to Troy 44-16.
Alabama, meanwhile, has not lost since Sept. 19, when Ole Miss left Bryant-Denny Stadium with a 43-37 victory.
The looming matchup will be the programs’ first meeting. Charleston Southern is 0-3 against SEC schools.