Tennessee opened as a 15-point favorite against South Carolina, according to VegasInsider.com.
The Vols are coming off a 52-21 win over Kentucky on Saturday, while South Carolina suffered a 35-28 defeat to Texas A&M.
The game will be held at 4 p.m. ET in Neyland Stadium and be broadcast on SEC Network. Tennessee has won two straight against the Gamecocks.